Monster Hunter follows Captain Natalie Artemis (played by Milla Jovovich), a U.S. Army Ranger who, along with her team, is transported to an alternate world populated by colossal and deadly monsters. Upon arrival, they quickly realize that their conventional weapons are nearly useless against these creatures, leaving them vulnerable in an unknown and perilous land. Struggling to survive, Artemis encounters a skilled Hunter (played by Tony Jaa) who teaches her the ways of this new world, equipping her to battle against the monstrous foes and uncover the mysteries of this hostile environment.

Captain Natalie Artemis is a brave and resourceful leader who, despite being out of her element, is determined to protect her team and make it back home. Her transformation from a conventional soldier to a warrior in a fantastical realm showcases her adaptability and resilience. The Hunter, a lone and seasoned warrior, becomes her unexpected ally, guiding her in mastering the weapons and tactics needed to face the towering creatures of his world. Their partnership grows as they confront insurmountable odds and learn to rely on each other.

The setting alternates between the harsh, barren deserts and the lush, vibrant landscapes of the alternate world, filled with massive, otherworldly creatures. The unpredictable and dangerous environment presents constant challenges, enhancing the sense of adventure and dread as Artemis and the Hunter venture deeper into monster territory.